miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA
نویسندگان
چکیده
منابع مشابه
miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPβ
MicroRNA-191 (miR-191), a small non-coding RNA, is involved in disease development and cancer diagnosis and prognosis. However, how miR-191 functions in colorectal cancer remains largely unclear. In this study, we show that miR-191 is highly expressed in colon tumor tissues, and that inhibition of miR-191 leads to decreased cell growth, proliferation and tumorigenicity in a xenograft model. Ove...
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The molecular mechanisms of hypoxia induced breast cell migration remain incompletely understood. Our results show that hypoxia through hypoxia-inducible factor (HIF) brings about a time-dependent increase in the level of an oncogenic microRNA, miR-191 in various breast cancer cell lines. miR-191 enhances breast cancer aggressiveness by promoting cell proliferation, migration and survival under...
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Themolecular mechanisms of hypoxia induced breast cell migration remain incompletely understood. Our results show that hypoxia through hypoxia-inducible factor (HIF) brings about a time-dependent increase in the level of an oncogenicmicroRNA,miR-191 in various breast cancer cell lines.miR-191 enhances breast cancer aggressiveness by promoting cell proliferation, migration and survival under hyp...
متن کاملmiR-191 Modulates Malignant Transformation of Endometriosis Through Regulating TIMP3
BACKGROUND Although aberrant expression of several miRNAs was found during the pathological development of endometriosis to endometriosis-associated ovarian cancer (EAOC), their roles are not fully understood. miR-191 is a miRNA significantly upregulated in endometriosis and EAOC patients. However, its downstream network is still not clear. This study explored its role in malignant transformati...
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Paclitaxel is a first-line microtubule-stabilizing drug in treating prostate cancer. However, most patients develop resistance and experience relapse. Morin (3,5,7,20,40-pentahydroxyflavone) is an anti-tumor flavonoid in a numerous types of cancer cells including breast, ovarian and lung cancers. We therefore researched the effects of morin as an adjuvant to paclitaxel in in treating DU145 and ...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2020
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2019.12.025